Hematopoietic mixed chimerism after allogenic BMT.
نویسندگان
چکیده
Chimerism after BMT has been documented by various genetic markers, RBC antigens, and, less frequently, by immunoglobulin allotypes. These markers are less sensitive than short tandem repeats (STRs), which provides a powerful tool for analysis of human polymorphisms. Application of STR analysis in patients undergoing allogeneic BMT has been used to detect mixed or complete chimerism, recurrent leukemia, and endogenous repopulation of marrow in early and late phases after transplant. It can detect minor populations of DNA in the period after transplant with adequate sensitivity, whereas traditional immunohematologic evaluation is limited because of the necessity of transfusing RBCs. 1
منابع مشابه
Relationship between Molecular Chimerism and Graft Versus Host Disease after Allogenic Hematopoietic Stem Cell Transplantation
Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...
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عنوان ژورنال:
- Transfusion
دوره 43 12 شماره
صفحات -
تاریخ انتشار 2003